Publications on Next Generation Insulin Analogs
Dr. Weiss's lab and its collaborators have published many articles on their work in insulin analogs. Some of these are listed below:
- Yang Y, Petkova A, Huang K, Xu B, Hua QX, Ye IJ, Chu YC, Hu SQ, Phillips NB, Whittaker J, Ismail-Beigi F, Mackin RB, Katsoyannis PG, Tycko R, Weiss MA. “ An Achilles' heel in an amyloidogenic protein and its repair: insulin fibrillationand therapeutic design. ”
J Biol Chem 285, 10806-21 (2010) - Yang Y, Hua QX, Liu J, Shimizu EH, Choquette MH, Mackin RB, Weiss MA “ Solution structure of proinsulin: connecting domain flexibility and prohormone processing. ”
J Biol Chem 285,7847-51 (2010) - Phillips NB, Wan ZL, Whittaker L, Hu SQ, Huang K, Hua QX, Whittaker J, Ismail-Beigi F, Weiss MA “ Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot ” J Biol Chem. 285,11755-59 (2010)
- Smith BJ, Huang K, Kong G, Chan SJ, Nakagawa S, Menting JG, Hu SQ, Whittaker J, Steiner DF, Katsoyannis PG, Ward CW, Weiss MA, Lawrence MC.. “ Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists ”
Proc Natl Acad Sci U S A. 107,6771-6 (2010) - Sohma Y, Hua, QX, Whittaker J, Weiss M.A., Kent SB
“ Design and Folding of [GluA4(OBThrB30)]Insulin (�Ester Insulin�), a Minimal Proinsulin Surrogate Chemically Convertible to Human Insulin. ” Angew. Chem. Int. Ed In press - Hua, Q., Xu, B., Huang, K., Hua, S. Q., Nakagawa, S., Jia, W., Wang, S., Whittaker, J., Katsoyannis, P. G. and Weiss, M. A. “Enhancing the activity of a protein by stereospecific unfolding: conformational life cycle of insulin and its evolutionary origins.” J. Biol. Chem. 284, 14586-96, (2009)
- Xu, B., Huang, K., Chu, Y. C., Hu, S. Q., Nakagawa, S., Wang, S., Wang, R. Y., Whittaker, J., Katsoyannis, P. G. and Weiss, M. A. “Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains.” J. Biol. Chem. 284, 14597-608, (2009)
- Weiss, M. A. “Proinsulin and the genetics of diabetes mellitus.” J. Biol. Chem. 284, 19159-63, (2009)