Successful candidate will have an MS degree and 5+ years experience in an industry setting working with proteins and performing purification techniques with high yield.  Individual must be meticulous, detail-oriented, responsible and mature.

Responsibilities

• Develop methods and GLP protocols for purifying novel insulins and their precursors
• Scale systems first for animal studies and eventually for clinical-scale production
• Perform assigned laboratory tasks safely, rapidly, and efficiently
• Optimize procedures and protocols to improve throughput;
• Write transferable, GLP-quality protocols
• Record results accurately and meticulously

Skills

• Excellent “hands” in laboratory protocols involving globular proteins
• Expertise with a variety of protein purification techniques:  preparative HPLC, gel filtration and ion exchange chromatography, microfiltration, and other related techniques as applied to materials from microbial expression sources (secreted & inclusion bodies) and chemical synthesis, at scales from micrograms to grams.
• Deep knowledge of solid and liquid phase protein chemistry and of how proteins behave under a variety of laboratory conditions  
• Experience with crystallization of bulk proteins desirable
• Proven ability to independently troubleshoot HPLC and other purification systems and protocols
• Experience with overcoming bottlenecks in scaling protein purification methods
• Pharmaceutical formulation of proteins compounds a plus
• GMP experience with protein products a plus
• Good project planning and time management which lead to timely task completion
• Juggling several simultaneous projects
• Good listener.  Strong, concise, and consistent written and oral communication

Background

• Must have 5 years in industry setting post PhD  or MS degree
• At least 3 distinct, observable examples where achieved meaningful excellence
• At least 3 years work focused on protein purification techniques
• Must have a Ph.D.  or MS in biochemistry or related science

For more information, contact Fran Rubin (Fran@thermalin.com)